Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma gondii strains to fetuses and protective effect of a chronic infection.
نویسندگان
چکیده
The incidence of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups from chronically infected mothers are protected from congenital toxoplasmosis, rat infection could thus constitute a relevant model for immunological studies and vaccine design.
منابع مشابه
بررسی مقایسهای عفونت مزمن توکسوپلاسموزیس مادرزادی با آلودگی مجدد در مدل حیوانی(رات)
Introduction: Toxoplasma gondii is a coccidian parasite and has, as intermediate hosts, many warm-blooded animals, including mammals and birds. Congenital toxoplasmosis is one of the most important infectious diseases seen in fetuses and infants born from mothers infected with Tox.gondii during pregnancy. Congenital infection, which may occur if a mother is infected for the first time during pr...
متن کاملRat Model of Congenital Toxoplasmosis: Rate of Transmission
The incidences of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups fro...
متن کاملSeroepidemiology of Toxoplasma infection of women in child-bearing ages in Chaharmahal va Bakhtiyari province, Iran
Introduction: Infection of pregnant women with Toxoplasma gondii during pregnancy may cause congenital toxoplasmosis in embryo and a number of serious and even persistent complications in newborns. One of the most effective factors determining the rate of congenital toxoplasmosis is the rate of Toxoplasma infection or immune status of women in child-bearing ages against the parasite.This study ...
متن کاملA Serological and Molecular study on Toxoplasma gondii infection in sheep and goat in Tabriz
Toxoplasmosis is an important zoonotic diseases in human and animals. The disease caused by the protozoan Toxoplasma gondii. To determine the infection rate of toxoplasmosis in sheep and goats in east Azarbaijan province of Iran a total of 186 sera, 13 fetal brains, 13 cotyledons and 34 whole blood samples were collected from sheep and goats in Tabriz abattoir during the year 2010. Serum sample...
متن کاملVaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB/c mice but not in CBA/J mice.
We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds. In BALB/c mice (H-2(d)), vaccination reduced the number of infected fetuses by 50% and was associated with a mixed type 1 and type 2 immunity. In CBA/J mice (H-2(k)), vaccination increased the number of infected fetuses by 50% and was ass...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Infection and immunity
دوره 61 1 شماره
صفحات -
تاریخ انتشار 1993